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X-ray lasers and the challenges facing structural sciences

Dvořákova přednáška
Středa, 27.05.2015 15:00 - 17:00

Přednášející: Prof. Janos Hajdu (Laboratory of Molecular Biophysics, Uppsala University, Sweden & the European XFEL GmbH, Hamburg, Germany)
Místo: Přednáškový sál Fyzikálního ústavu AV ČR, Pod Vodárenskou věží 1, Praha 8
Jazyk: anglicky
Pořadatelé: FZÚ AV ČR

The 7th Dvořák Lecture

Theory predicts that with an ultra-short and extremely bright coherent X-ray pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus, or a cell before the sample explodes and turns into a plasma. The over-sampled diffraction pattern permits phase retrieval and hence structure determination. X-ray lasers capable to deliver ultra bright and very short X-ray pulses for such experiments have recently started operations. Free-electron lasers are the most brilliant sources of X-rays to date, exceeding the peak brilliance of conventional synchrotrons by a factor of 10 billion, and improving. In the duration of a single fl ash, the beam focused to a micron-sized spot has the same power density as all the sunlight hitting the Earth, focused to a millimetre square. The interaction of an intense X-ray pulse with matter is profoundly diff erent from that of an optical pulse. Our aim in biology is to step beyond conventional damage limits and develop the science and technology required to enable high-resolution imaging of biological objects. The talk will summarise imaging results from the Linac Coherent Light Source, including studies on live cyanobacteria.