Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations


Currently, interest in biomedical applications of low temperature plasmas is rapidly growing. However, the understanding of the molecular mechanisms behind low temperature plasma cellular effects remains a significant challenge. In a recent study, we showed how different low temperature plasmas induce cell death via the formation of multiple intracellular reactive oxygen/nitrogen species. Our results suggest that the biological response to low temperature plasma treatment greatly depends on: cell type, chemical composition of plasma and exposition length. Variation of these parameters enables purposeful use of low temperature plasma in broad range of biomedicinal applications.

(a) plasma jet, (b) plasma jet cross-section, (c) deactivation of P. aeruginosa and S. aureus bacterias using ozone, helium and atmospheric plasma, (d) AFM analysis of cell membrane's surface influenced by ozone, helium and atmospheric plasma.