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Hydroxyl radicals (·OH) generated by pulsed soft x-ray radiation source in the so-called water window are tracked in the reaction and time domain. Time development of the ·OH radiation-chemical yield was revealed from its reactivity towards DNA molecules. Results showed that the water window photons behave as radiation with high linear energy transfer (LET) and that the pulsed source can be used to study the mechanisms where radiation is delivered at very high dose rates (i.e., FLASH effect).
Description
Radiation chemical yield of ·OH radicals in the presence of different concentrations of the substrates (DNA and buffer salts) generated by gamma, Al Kα, and the water window radiation (WW) (left). Temporal development of the radiation chemical yield revealed using the inverse Laplace transform method (right). Yields of ·OH radicals for different radiation sources characterized by different linear energy transfer (LET) coefficients are shown for comparison.