Laser irradiation and cellular responses


A burst of research in this direction resulted in therapeutic applications of low power red and near-infrared light to promote wound healing, hair growth, tissue regeneration, reduce pain, etc. However, many of such investigations are hampered by shortcomings in experimental design and often also by a lack of reproducibility. Thus, rigorous research of detailed biophysical mechanisms of laser-cell interactions are of a great value.
Additionally, similar high fluence low-power laser irradiation is utilized in super-resolution localization microscopy. Unfortunately, so far live-cell super-resolution localization microscopy largely ignored possible phototoxic effects. Therefore, we aim to understand the molecular basis that drives phototoxic effects to be able to significantly improve imaging techniques.

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