DNA-based structural nanotechnology offers unique opportunities to overcome persistent challenges in the field of nanobiotechnology. Self-assembled DNA nanostructures (DNs) can be designed in a controlled and programmable manner, and these structures are increasingly used in a variety of biomedical applications, such as the delivery of therapeutic agents.
However, the interactions between engineered DNs and living cells are still not well understood. For the successful translation of DNA technology to real-world applications, it is crucial to understand how DNA nanostructures interact with living cells and the consequences of such interactions.
We study the interactions between distinctly designed DNs and both primary cells and tumor cell lines. Our research aims to identify potential receptors, target molecules, and cell functions that may be influenced by DNs. Specifically, we are interested in the possibility of modulating the immune response through functionalized DNs.
By enhancing our understanding of these interactions, we hope to create the way for the development of more effective and safer DNA-based therapies and contribute to the broader field of nanomedicine.
