Structural study of antioxidant-loaded nanoparticles for neuroregeneration


Natural and designed therapeutics based on proteins, peptides, oligonucleotides, and antioxidants quercetin and curcumin, are gaining tremendous current interest owing to their success in clinical development as compared to conventional small organic molecule drugs. We aim to develop formulations of nanostructured lipid dispersions and biocolloids for neuroregenerative drug delivery applications. The nanoorganization of liquid crystalline carriers (spongosomes, cubosomes, and hexosomes) will be tuned for successful encapsulation and protection of biomolecules of different sizes. Small-angle neutron (SANS) and X-ray scattering (SAXS) and cryo-transmission electron microscopy (cryo-TEM) will be used for structural information into the mechanism of formation of the proposed nanoparticles.