Improved osseointegration of bone implants with the use of ferroelectric coatings

Ageing of the population has led in an increasing need for bone and joint tissue replacements. Novel types of alloys have been developed, together with modifications of the physicochemical properties of the surface to accelerate the osseointegration of bone implants. The creation of electrically active surfaces is a promising approach. The aim of the project is to provide solutions to problems of osseointegration that often arise in orthopaedic surgery. Permanent bone implants from titanium alloy (screws), including 3D printed titanium with trabecular structure, will be covered with electrically active surfaces to support osseointegration of artificial materials into the bones. The osteogenic potential of the ferroelectric layers will be tested in vitro (in static culture and using mechanical loading of the samples seeded with bone-derived cells). Markers of cell adhesion, growth, and differentiation will be evaluated. The most promising coating will be tested in vivo. The implants will be inserted into the tibia of miniature pigs, and histological analyses will be performed.