Hepatotoxicity has been the second most common reason for the withdrawal of drugs from the market. Current preclinical toxicological approaches have proven inadequate in predicting these adverse events. To address this critical gap, we aim to enhance existing and potential in vitro models of hepatotoxicity, including dynamic 3-D culture systems. Our goal is to critically appraise the strengths, limitations, and applications of these models in preclinical evaluation.
In our research, we focus on advancing physics-based biomedical approaches to improve hepatotoxicity studies. By integrating interdisciplinary methodologies, we aim to develop more accurate and reliable models that can better predict hepatotoxic effects, ultimately contributing to safer drug development and reducing the incidence of drug-induced liver injuries.
