Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations

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Currently, interest in biomedical applications of low temperature plasmas is rapidly growing. However, the understanding of the molecular mechanisms behind low temperature plasma cellular effects remains a significant challenge. In a recent study, we showed how different low temperature plasmas induce cell death via the formation of multiple intracellular reactive oxygen/nitrogen species. Our results suggest that the biological response to low temperature plasma treatment greatly depends on: cell type, chemical composition of plasma and exposition length. Variation of these parameters enables purposeful use of low temperature plasma in broad range of biomedicinal applications.

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Description
(a) plasma jet, (b) plasma jet cross-section, (c) deactivation of P. aeruginosa and S. aureus bacterias using ozone, helium and atmospheric plasma, (d) AFM analysis of cell membrane's surface influenced by ozone, helium and atmospheric plasma.