Spatiotemporal magnetic fields enhance cytosolic Ca²⁺ levels and induce actin polymerization via activation of voltage-gated sodium channels in skeletal muscle cells

Cell membrane potential can be modified by spatially and temporally dependant magnetic fields (ST-MF), which we demonstrate by controlling intracellular signalisation of skeletal muscles. The exposition of such cells to ST-MP causes significant increase of the cytostolic Ca²⁺  level leading to actin polymerization. We have identified cellular effectors of the ST-MF and proposed new opportunities to anticipate effects related to membrane depolarisation. The use of ST-MP for the modulation of cellular functions opens up new possibilities for the treatment of a number of myopathies.