Advanced physical methods in hepatotoxicity studies

Hepatotoxicity has been the second most common reason for withdrawal of drugs from the market. Current preclinical toxicological approaches are unsuccessful in predicting these adverse events. Therefore, we are aiming to improve current and potential in vitro models of hepatotoxicity including dynamic 3-D culture systems and critically appraise their strengths, limitations and applications in pre-clinical evaluation. We elaborate physics-based biomedical approaches for the advancements in hepatotoxicity research.