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We prepared and tested cobalt zinc ferrite encapsulated by amorphous silica in order to find a safe contrast agent and magnetic label MRI. Rat mesenchymal stem cells were labeled with a low, medium or high dose of CZF-NPs (0.05; 0.11 or 0.55 mM); silica NPs served as a positive control. Annexin V/Propidium Iodide labeling revealed no significant cytotoxicity for any group of treated cells and only a high dose of CZF-NPs slowed down cell proliferation and induced DNA damage. Nevertheless, the labeled cells still exhibited an adequate relaxation rate for MRI.
Description
Cobalt zinc ferrite encapsulated by amorphous silica in order to find a safe contrast agent and magnetic label MRI.