Heterogenous diamond biosensing nanoarchitectures: opto-electro-chemical interactions with antibody complexes (D4CZaPLa)

Abstract

High demand for pathogen detection gives boost to research trends focusing on the

development of fast, highly sensitive, label-free, miniature devices. The use of diamond in such

structures allows for taking advantage of its unprecedented set of properties as high chemical

stability, optical transparency, electronic functionality and robust biointerfaces and

biocompatibility. The idea is not only to enhance analyte diffusion and surface area, but more

importantly to explore physico-chemical phenomena that would change our view on the present

biosensing concepts. The aim of the D4CaPLa project is to take advantage of the latest

advances in diamond nanotechnology and biosensing achieved in the PL and CZ teams and

thereby design, produce, and analyse function of new heterogeneous diamond

nanoarchitectures enhanced with Au-nanoparticles and bio-functionalized with antibody

receptors. A unique approach is the characterization (and control) of combined optical and

electrochemical processes and signals, with view to improving recognition of virus antigens