Chiral HPLC separation

We develop and optimize separation methods on chiral stationary phases for ferroelectric liquid crystalline materials on an analytical scale.

We study the effect of various lateral substitutions in the molecule core on the separation behavior of individual liquid crystalline materials using different chiral stationary phases in normal separation mode.

We intensively study the effect of photoisomerization of azo-group in the liquid crystalline skeleton on the separation behavior of individual materials.

Development and optimization of chiral methods is performed in the analytical scale using a DAD detector capable of recording 3D spectra. An essential part of the device is a thermostat for the separation column.

Chromatograms of the racemic mixture and pure (S) –enantiomer of photosensitive material. Separation of the racemic mixture (a) and pure (S) -enantiomer (b) measured in the dark, and separation of the same materials after UV irradiation, the racemic mixture (c) and the pure (S) -enantiomer (d). The separation conditions are described in the article from which the image is taken from DOI: 10.1002 / jssc.201601386

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