The PRO-EURO-DILI-NET consortium, which also included the Laboratory of Biophysics team from the Division of Optics, was evaluated as the best project within the COST Action programme.
A new study by scientists led by Oleg Lunov of the Division of Optics of the Institute of Physics of the Czech Academy of Sciences sheds light on how a cell's shape and mechanics influence its absorption of drug carriers.
After two and a half years of intensive work, scientists from the Laboratory of Biophysics of the Institute of Physics of the Czech Academy of Sciences, led by Oleg Lunov, have presented a breakthrough DNA nanostructure based platform, which allows for the targeted influence of lysosomal functions in cells.
The PRO-EURO-DILI Network, an international consortium of scientists investigating drug-induced liver injury, including scientists from the Laboratory of Biophysics, Division of Optics, Institute of Physics of the Czech Academy of Sciences, has presented a revolutionary advance in the development of liver organoids. The results of the research have been published in the prestigious Experimental and Molecular Medicine journal belonging to the Nature family.
Active substances of drugs, alone or in combination with each other, herbs and herbal supplements are metabolized by the human liver. This metabolization can be associated with irreversible damage or even death of the patient. There is no effective prevention against this problem. Additionally, there is no simple drug testing preclinical system to decipher hepatotoxicity issues undoubtfully at early stages of the drug development.
Scientists from the Laboratory of Biophysics contributed to the field of DNA nanotechnology with a recent systematic analysis. The authors, led by Oleg Lunov, have summarized the current state of knowledge about the interactions of DNA nanostructures (DN) with cells and identified the key challenges.
Targeted drug delivery is a topic of interest to scientists around the world. A new contribution to this area has now been made by researchers from the Laboratory of Biophysics led by Oleg Lunov from the Division of Optics. The group was exploring biological properties and the efficiency of cellular delivery using DNA nanostructures (DN).
How can physicists contribute to dealing with drug-induced liver injury? The answer to this question is, for example, by applying cutting-edge imagining techniques. Researchers from the Institute of Physic of the Czech Academy of Sciences have joined an international interdisciplinary research team which is conducting a research to generate new knowledge and approaches to dealing with drug-induced liver injury, aiming to create a liver model for timely detection of drug toxicity. A comprehensive interdisciplinary research summary of this subject was published in the prestigious Journal of Hepatology.
A research team of the Laboratory of Biophysics won the Cells 2021 Best Video Abstract Awards contest. The winning video abstract of the Biophysics team is a crisp illustration of the research paper, published in journal Cells. The Award Committee highly evaluated the research novelty, video quality and votes of the readers.
Interdisciplinary research of the Laboratory of Biophysics aims to gain insight in the understanding of how physical factors influence the processes that drive cell behaviour and functionality. The Czech Academy of Sciences supported the laboratory by providing funds for the CytoFLEX Beckman Coulter flow cytometer.
The nomination for the annual Otto Wichterle Premium is intended for outstanding young scientists up to the age of thirty-five employed at the Academy of Sciences who achieved top results in their fields.
