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Slow scintillation components due to charge carrier capture at defects are detrimental for material performance. Using the defect engineering strategy in advanced optical Lu3Al5O12:Ce,Mg ceramics, such processes are minimized and time response accelerated. The optimized 0.3 at% Mg2+-codoped ceramics shows the 0.5µs/10µs light yield’s ratio of 99.8%, which is the best value among the reported isostructural materials. We discuss the role of Mg2+ co-doping and pathways of performance optimization.